Method 6001


This method is for the determination of arsine from a workplace air sample.  The samlpe is collected on a charcoal tube and desorbed in 1 mL of 0.01 M nitric acid.  The method calls for sample analysis by graphite furnace atomic absorption (GFAA) however most labs have now perform the analysis using ICP/MS.  ICP/MS is an new technique that has less interferences and achieves lower detection limits than GFAA.

Any arsenic detected in the sample is assumed to be from arsine.

The working range of the method is 0.0003 to 0.06 ppm (0.001 to 0.2 mg/m³ ) for a 10-L air sample.

Note: This method combines and replaces P&CAM 265 and S229 for arsine.

(NIOSH Issue 2: 15 August 1994)


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Method Data

Hold Times, Preservatives, Preps, Collection, Analytical & Documentation
Holding Time:   Per the method, at least 6 days if kept at 25°C.
Preservatives:   Keep samples at 25°C.
Required Preps:   Charcoal tube 100mg/50mg (SKC 226-01)
Collection Method:   The method recommends a 0.01 - 0.2 L/min. flow rate with a 0.1 -10L sample collection volume.
Analytical Methodology:   ICP/MS
Documentation:   6001

Analyte List*

Analyte Formula CAS Number Detection Limit

* The analytes and detection limits listed for each method represent the typical detection limits and analytes reported for that particular method. Keep in mind that analyte lists may vary from laboratory to laboratory. Detection limits may also vary from lab to lab and are dependent upon the sample size, matrix, and any interferences that may be present in the sample.