This method is for the determination of monomeric isocyantes. Samples are collected through an impinger containing a solution of 1-(2-methoxyphenyl)-piperazine in toluene. The excess reagent is acetylated, the toluene is evaporated, and the sample is redissolved in methanol, followed by HPLC analysis with electrochemical and ultraviolet detection. The working range is from 5 µg/m³ 2,4-TDI, 7 µg/m³ 2,6-TDI, 3 µg/m³ MDI, 1 µg/m³ HDI, and 2 µg/m³ NDI to more than 1 mg/m³ for 100-L air samples. This method determines the air concentration of specific diisocyanates. The method has been applied to samples from general foaming, spray- or dip-painting industries. Note: This method is a modification of Method MDHS 25 published by the Health and Safety Executive of Great Britain.
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| Hold Times, Preservatives, Preps, Collection, Analytical & Documentation | |
|---|---|
| Holding Time: | May be unstable; analyze as soon as possible. |
| Preservatives: | Store (and ship) at 4°C or lower. |
| Required Preps: | Impinger containing a solution of 1-(2-methoxyphenyl)-piperazine in toluene. |
| Collection Method: | Impinger: 5L - 500L @ 1L/min. |
| Analytical Methodology: | HPLC with electrochemical and ultraviolet detection. |
| Documentation: | 
5521
|
| Analyte | Formula | CAS Number | Detection Limit | |
|---|---|---|---|---|
| Methylene diphenyl isocyanate (MDI) | C15H10N2O2 |
101-68-8 |
0.1 |
µg |
| 1,5-Naphthalene diisocyanate | C12H6N2O2 |
3173-72-6 |
0.1 |
µg |
| 2,4-Toluene diisocyanate (TDI) | C9H6N2O2 |
584-84-9 |
0.1 |
µg |
| 1,6-Hexamethylene diisocyanate (HDI) | C8H12N2O2 |
822-06-0 |
0.1 |
µg |
| Toluene-2,6-Diisocyanate | C9H6N2O2 |
91-08-7 |
0.1 |
µg |
* The analytes and detection limits listed for each method represent the typical detection limits and analytes reported for that particular method. Keep in mind that analyte lists may vary from laboratory to laboratory. Detection limits may also vary from lab to lab and are dependent upon the sample size, matrix, and any interferences that may be present in the sample.