This method is used for the determination of polychlorinated biphenyls (PCBs) at low levels from soil, sediment, and biosolid samples using isotope dilution HRMS (high resolution mass spectrometry). All 209 individual PCBs are determined as well as the Totals for each congener group (e.g. Total Mono-PCB, Total Di-PCB). Special interest is paid to the twelve PCBs designated by the World Health Organization (WHO) as the most toxic. This subset of PCBs may also be called the co-planar or dioxin-like PCBs. It is not currently possible to separate each of the 209 PCBs and some are reported as co-eluting compounds.
Wrap the samples in foil since the method requires the samples be protected from light. Ideally, tissue samples should be frozen and shipped on dry ice. Samples should be stored at <-10°C.
Samples are typically extracted with methylene chloride using a 10 gram wet weight equivalent sample size adjusted for lipids. A lipid determination is required. Keep in mind that this is a performance based method so lab procedures may vary. Because of the variances in tissue, it's important that the samples are thoroughly homogenized prior to extraction. If possible, it's best to homogenize them while frozen.
The sample extracts undergo an extensive cleanup prior to analysis in order to remove interferences (dioxins, pesticides, PAH, etc.) in order to achieve the low limits of detection.
NOTE: This method is an update of and replaces Methods 1668, 1668A and 1668B.
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| Hold Times, Preservatives, Preps, Collection, Analytical & Documentation | |
|---|---|
| Holding Time: | The method states that samples are good for up to one year if kept in the dark and at less than -10°C. |
| Preservatives: | None specified in method although it's recommended to ship the samples frozen and on dry ice. |
| Required Preps: | 4oz Amber glass bottle with Teflon-lined lid |
| Collection Method: | Various techniques |
| Analytical Methodology: | HR GC/MS |
| Documentation: | 
1668C
|
* The analytes and detection limits listed for each method represent the typical detection limits and analytes reported for that particular method. Keep in mind that analyte lists may vary from laboratory to laboratory. Detection limits may also vary from lab to lab and are dependent upon the sample size, matrix, and any interferences that may be present in the sample.