Method 2522

Nitrosamines


This method is for the collection and analysis of nitrosamines.  The sample is collected on a Thermosorb/N tube.  After collection the sample is desorbed in 2 mL 3:1 (v/v) dichloromethane/methanol and analyzed by GC with a thermal energy analyzer.  When the thermal energy analyzer (TEA) is operated in the nitrosamine mode, it is highly specific for N-nitroso compounds.  Most labs now substitute another nitrogen sensitive detector such as an NPD (nitrogen phosphorus detector) which is more common and gets equivalent detection limits.  If high ambient concentrations of nitrosamines are expected, another Thermosorb/N tube should be used as a back-up in sampling.

The working range of the method is 0.003 to 10 mg/m³ for a 50 L air sample.

NOTE: This method replaces NIOSH methods P&CAM 252 and P&CAM 299.


(NIOSH Issue 2: 15 August 1994)

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Method Data

Hold Times, Preservatives, Preps, Collection, Analytical & Documentation
Holding Time:   The method says at least 6 weeks from sampling to analysis if samples are kept at 20°C.
Preservatives:   Store samples at 20°C.
Required Preps:   Thermosorb/N sorbent tube
Collection Method:   The method recommends a flow rate of 0.2 - 2L/min. with a 15 - 1000L sample collection volume.
Analytical Methodology:   GC/TEA or GC/NPD
Documentation:   2522

Analyte List*

Analyte Formula CAS Number Detection Limit
1-Nitrosopiperidine
C5H10N2O
100-75-4
0.05
 µg
N-Nitrosodiethylamine
C4H10N2O
55-18-5
0.05
 µg
N-Nitrosomorpholine
C4H8N2O2
59-89-2
0.05
 µg
N-Nitrosodipropylamine
C6H14N2O
621-64-7
0.05
 µg
N-Nitrosodimethylamine
C2H6N2O
62-75-9
0.05
 µg
N-Nitrosodi-n-butylamine
C8H18N2O
924-16-3
0.05
 µg
1-Nitrosopyrrolidine
C4H8N2O
930-55-2
0.05
 µg

* The analytes and detection limits listed for each method represent the typical detection limits and analytes reported for that particular method. Keep in mind that analyte lists may vary from laboratory to laboratory. Detection limits may also vary from lab to lab and are dependent upon the sample size, matrix, and any interferences that may be present in the sample.